2002•Journa of Henan Medical UniversityRequires access
Deletion of WTl and P53 genes in Wilms' tumor tissues
Pan Zhouhui
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Abstract
Am:To study WT1 and P53 gene from 30 cases of sporadic Wilms' tumor. Methods: WT1 and P53 genes in 30 sporadic Wilms' tumor tissues (6 epithelium predominated Wilms' tumor, 14 metrocyte predominated Wilms', and 10 stroma predominated Wilms' tumor) were studied by southern bolt hybridization with WT1 cDNA and P53 cDNA probes. Results: Two cases with intragenic deletions of WT1 gene were histologically classified as stroma predominated Wilm's tumor. One case with allelic deletion of P53 was anaplastic Wilms' tumor. Conclusions: The deletion of WT1 gene may be correlated with stroma predominated Wilms' tumor and the P53 alteration may be correlated with the anaplasia of Wilms' tumor.