ScholarLens Back to search
2001•Acta Universitatis Medicinalis Secondae ShanghaiRequires access

Effect of over Expression of P53 and C-erbB-2 on Prognosis of Breast Cancer

Yong Pu

Open publisher page 0 citations

Abstract

Objective The purpose of this study is to assess the prognostic significance of over expression of P53, C-erbB-2 in breast cancer. In 48 patients with breast cancer the expression of P53, C-erbB-2, PCNA and ER was determined by the S-P staining immunohistochemical technique. The positive rate of P53, C-erbB-2, PCNA and ER were 54%, 43.7% 52%, 41.6% seperateiy. Expression of P53 and C-erbB-2 increased with the class of the tissuess. There is significant difference between grade Ⅰ and Ⅱ , Ⅲ (P0.05) as well as between lymph node metastasis (+) and lymph node metastasis (-) patients (P0.05). The over expression of P53, C-erbB-2 may be a useful prognostic indicator in breast cancer.

About this research paper

What this paper is about

Objective The purpose of this study is to assess the prognostic significance of over expression of P53, C-erbB-2 in breast cancer. In 48 patients with breast cancer the expression of P53, C-erbB-2, PCNA and ER was determined by the S-P staining immunohistochemical technique. The positive rate of P53, C-erbB-2, PCNA and ER were 54%, 43.7% 52%, 41.6% seperateiy. Expression of P53 and C-erbB-2 increased with the class of the tissuess. There is significant difference between grade Ⅰ and Ⅱ , Ⅲ (P0.05) as well as between lymph node metastasis (+) and lymph node metastasis (-) patients (P0.05). The over expression of P53, C-erbB-2 may be a useful prognostic indicator in breast cancer.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective The purpose of this study is to assess the prognostic significance of over expression of P53, C-erbB-2 in breast cancer. In 48 patients with breast cancer the expression of P53, C-erbB-2, PCNA and ER was determined by the S-P staining immunohistochemical technique. The positive rate of P53, C-erbB-2, PCNA and ER were 54%, 43.7% 52%, 41.6% seperateiy. Expression of P53 and C-erbB-2 increased with the class of the tissuess. There is significant difference between grade Ⅰ and Ⅱ , Ⅲ (P0.05) as well as between lymph node metastasis (+) and lymph node metastasis (-) patients (P0.05). The over expression of P53, C-erbB-2 may be a useful prognostic indicator in breast cancer.

Key concepts: Breast cancer, Immunohistochemistry, Medicine, Lymph node, Lymph node metastasis, Oncology, Metastasis, Internal medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of over Expression of P53 and C-erbB-2 on Prognosis of Breast Cancer — Research Paper | ScholarLens