ScholarLens Back to search
2007•Jiangsu Medical JournalRequires access

Expression of p53 and C-erbB-2 in 240 cases with breast cancer tissue

Xia Tianson

Open publisher page 0 citations

Abstract

Objective To study the expression of p53 and C-erbB-2 in 240 cases with breast cancer.Methods The p53 and C-erbB-2 were detected with immunohistochemical stain method in 240 breast tissues. The relationship between p53 and C-erbB-2 and some clinicopathological factors were analyzed.Results The positive p53 and C-erbB-2 were mostly located in nucleus with the rates of 53.3% and 63.3%,respectively. The expression levels of p53 and C-erbB-2 were correlated possitively with histological grade (P0.05) and axillary lymph node metastases(P0.05), which were not with PR and ER status(P0.05). Conclusions The p53 and C-erbB-2 play a role in the oncogenesis and development of breast cancer and their expression could be the useful indexes to assess the malignant level of breast carcinoma and its clinical prognosis.Expression of p53 and axillary lymph node metastases may be an independent prognostic indicator of operative survival in breast cancer patients.

About this research paper

What this paper is about

Objective To study the expression of p53 and C-erbB-2 in 240 cases with breast cancer.Methods The p53 and C-erbB-2 were detected with immunohistochemical stain method in 240 breast tissues. The relationship between p53 and C-erbB-2 and some clinicopathological factors were analyzed.Results The positive p53 and C-erbB-2 were mostly located in nucleus with the rates of 53.3% and 63.3%,respectively. The expression levels of p53 and C-erbB-2 were correlated possitively with histological grade (P0.05) and axillary lymph node metastases(P0.05), which were not with PR and ER status(P0.05). Conclusions The p53 and C-erbB-2 play a role in the oncogenesis and development of breast cancer and their expression could be the useful indexes to assess the malignant level of breast carcinoma and its clinical prognosis.Expression of p53 and axillary lymph node metastases may be an independent prognostic indicator of operative survival in breast cancer patients.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the expression of p53 and C-erbB-2 in 240 cases with breast cancer.Methods The p53 and C-erbB-2 were detected with immunohistochemical stain method in 240 breast tissues. The relationship between p53 and C-erbB-2 and some clinicopathological factors were analyzed.Results The positive p53 and C-erbB-2 were mostly located in nucleus with the rates of 53.3% and 63.3%,respectively. The expression levels of p53 and C-erbB-2 were correlated possitively with histological grade (P0.05) and axillary lymph node metastases(P0.05), which were not with PR and ER status(P0.05). Conclusions The p53 and C-erbB-2 play a role in the oncogenesis and development of breast cancer and their expression could be the useful indexes to assess the malignant level of breast carcinoma and its clinical prognosis.Expression of p53 and axillary lymph node metastases may be an independent prognostic indicator of operative survival in breast cancer patients.

Key concepts: Breast cancer, Medicine, Immunohistochemistry, Lymph node, Carcinogenesis, Breast carcinoma, Oncology, Stain

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression of p53 and C-erbB-2 in 240 cases with breast cancer tissue — Research Paper | ScholarLens