Study on Influence of Piyankang Granules on NF-кBp50 Positive Cell Expressions in Mice

Objective :To discuss the influence of Piyankang Granules on NF-кBp50 positive cell expressions in mice. Methods :The ACD model was established with DNCB. There were Piyankang Granules high,middle and low dose groups,Lomtadine high dose group,blank group and model group. The influence on NF-кBp50 was observed. Results :The model group compared with blank group,the expression of NF-кBp50 in mice was significantly increased. There was significant difference between the two groups(P0.05). Piyankang Granules in each dosage group and Lomtadine high dose group compared with the model group could obviously reduce the expression of NF-кBp50 in mice with DNCE-induced ACD. There were significant differences between the two groups(P0.01 or P0.05). Conclusion :Piyankang Granules can obviously reduce the expression of NF-кBp50 in mice with DNCE-induced ACD,which is one of the functions of Piyankang Granules to regulate the immune system and inflammation.