INHIBITION OF SUB-CONJUNCTIVAL INJECTION OF TRIAMCINOLONE ACETONIDE ON CORNEAL NEOVASCULARIZATION:AN EXPERIMENTAL STUDY

Objective To study the inhibition of Triamcinolone Acetonide(TA) on corneal neovascularization(CNV) in rats.Methods A model of corneal neovascularization was created in 44 healthy rats by using alkali burn,which were evenly divided into control group-normal saline was injected sub-conjunctivally;TA group-subconjunctival injection of TA(2 mg).The proportion of the area of CNV occupying the total area of cornea was observed,the histology and ultra-structure of cornea were investigated under light microscopy and transmission electron microscopy.Results After 14 and 28 days of creation of the model,in TA group,the area of CNV accounted for 45.0%±14.7% and 46.0%±16.5% of the total area of cornea,respectively;in control group,that was 60.1%±10.5% and 72.0%±11.1%,the differences being significant between the two groups(t=5.187,5.340;P0.01).Microscopy indicated no obvious toxic effect caused by subconjunctival injection of TA.Conclusion Sub-conjunctival injection of TA may inhibit neovessels in cornea,and it does not appear any toxic effect on its ultra-structure.