ScholarLens Back to search
2005•Clinical Medical Journal of ChinaRequires access

Apoptosis of Pancreatic Cell Participates in the Pathological Process in Rats with SAP

Lou Wenhui

Open publisher page 0 citations

Abstract

Objective: To investigate the role of apoptosis of pancreatic cell in the pathological process in rats with acute pancreatits(SAP). Methods;68 SD rats were randomly divided to 2 groups :SAP group and contrel group. SAP group was submitted to injection of sodium taurocholate under the pancreatic capsule to induce severe acute pancreatitis and jejunostomy was performed. The control had sham operation only. At 12,24,36hours after the induction of SAP,8 rats in each group were killed. The histological severity were assessed by Schmidt method. The apoptotic rate of pancreatic cell determined. One week mortality was calculated. Results: Obvious pathologic changes were observed in pancreas and the apoptotic rate of pancreatic cell in SAP groups were much higher than that in the control group(P0. 01). The mortality rate was 12. 5% in 24h,90% in a week. Conclusion: Apoptosis of pancreatic cell participates in the whole pathological process in rats with SAP.

About this research paper

What this paper is about

Objective: To investigate the role of apoptosis of pancreatic cell in the pathological process in rats with acute pancreatits(SAP). Methods;68 SD rats were randomly divided to 2 groups :SAP group and contrel group. SAP group was submitted to injection of sodium taurocholate under the pancreatic capsule to induce severe acute pancreatitis and jejunostomy was performed. The control had sham operation only. At 12,24,36hours after the induction of SAP,8 rats in each group were killed. The histological severity were assessed by Schmidt method. The apoptotic rate of pancreatic cell determined. One week mortality was calculated. Results: Obvious pathologic changes were observed in pancreas and the apoptotic rate of pancreatic cell in SAP groups were much higher than that in the control group(P0. 01). The mortality rate was 12. 5% in 24h,90% in a week. Conclusion: Apoptosis of pancreatic cell participates in the whole pathological process in rats with SAP.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective: To investigate the role of apoptosis of pancreatic cell in the pathological process in rats with acute pancreatits(SAP). Methods;68 SD rats were randomly divided to 2 groups :SAP group and contrel group. SAP group was submitted to injection of sodium taurocholate under the pancreatic capsule to induce severe acute pancreatitis and jejunostomy was performed. The control had sham operation only. At 12,24,36hours after the induction of SAP,8 rats in each group were killed. The histological severity were assessed by Schmidt method. The apoptotic rate of pancreatic cell determined. One week mortality was calculated. Results: Obvious pathologic changes were observed in pancreas and the apoptotic rate of pancreatic cell in SAP groups were much higher than that in the control group(P0. 01). The mortality rate was 12. 5% in 24h,90% in a week. Conclusion: Apoptosis of pancreatic cell participates in the whole pathological process in rats with SAP.

Key concepts: Pathological, Apoptosis, Acute pancreatitis, Pancreas, Medicine, Pancreatitis, Internal medicine, Cell

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Apoptosis of Pancreatic Cell Participates in the Pathological Process in Rats with SAP — Research Paper | ScholarLens