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2011•The Journal of Medical Theory and PracticeRequires access

Effect of Nucleoside Drugs in Treating the Liver Decompensation of Hepatitis B Cirrhosis

Zheng Sujin

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Abstract

Objective:To observe the effect of nucleoside drugs in treating the liver decompensation of hepatitis B cirrhosis.Methods:Forty-eight patients with hepatitis B cirrhosis of the liver decompensation were divided into three groups(A,B,C).All were treated in a basic treatment.A and B group were given by lamivudine(100mg/d)and adefovir(10mg/d) respectively.C group was a control.The course lasted 48 weeks.The clinic symptoms,change of liver function,PTA,quantitative HBV-DNA,HBeAg/HBeAb transformation were observed.Results:After antiviral treatment,A and B group had no deaths,and the clinic symptoms,change of liver function,PTA had improved obviously.C group had 2 cases died.The curative effect of two groups had the remarkable difference than the control(P0.01).Conclusion:The patients with hepatitis B cirrhosis of the liver decompensation should accept a antiviral treatment.Lamivudine or adefovir of nucleoside drugs can be as a top choice.

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Objective:To observe the effect of nucleoside drugs in treating the liver decompensation of hepatitis B cirrhosis.Methods:Forty-eight patients with hepatitis B cirrhosis of the liver decompensation were divided into three groups(A,B,C).All were treated in a basic treatment.A and B group were given by lamivudine(100mg/d)and adefovir(10mg/d) respectively.C group was a control.The course lasted 48 weeks.The clinic symptoms,change of liver function,PTA,quantitative HBV-DNA,HBeAg/HBeAb transformation were observed.Results:After antiviral treatment,A and B group had no deaths,and the clinic symptoms,change of liver function,PTA had improved obviously.C group had 2 cases died.The curative effect of two groups had the remarkable difference than the control(P0.01).Conclusion:The patients with hepatitis B cirrhosis of the liver decompensation should accept a antiviral treatment.Lamivudine or adefovir of nucleoside drugs can be as a top choice.

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Available abstract

Objective:To observe the effect of nucleoside drugs in treating the liver decompensation of hepatitis B cirrhosis.Methods:Forty-eight patients with hepatitis B cirrhosis of the liver decompensation were divided into three groups(A,B,C).All were treated in a basic treatment.A and B group were given by lamivudine(100mg/d)and adefovir(10mg/d) respectively.C group was a control.The course lasted 48 weeks.The clinic symptoms,change of liver function,PTA,quantitative HBV-DNA,HBeAg/HBeAb transformation were observed.Results:After antiviral treatment,A and B group had no deaths,and the clinic symptoms,change of liver function,PTA had improved obviously.C group had 2 cases died.The curative effect of two groups had the remarkable difference than the control(P0.01).Conclusion:The patients with hepatitis B cirrhosis of the liver decompensation should accept a antiviral treatment.Lamivudine or adefovir of nucleoside drugs can be as a top choice.

Key concepts: Adefovir, Medicine, Decompensation, Lamivudine, Cirrhosis, HBeAg, Gastroenterology, Liver function

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