Pharmacodynamic effect of enrofloxacin against Aeromonas hydrophila in vitro pharmacokinetic model

The purposes of this research is to decrease the occurrence speed of resistant Aeromonas hydrophila and prolong the time limit of enrofloxacin application on aquatic creature.By using in vitro pharmacokinetic model,PK-PD parameter of Aeromonas hydrophila against enrofloxacin was studied.In the in vitro model with elimination half-life of 100 h,Aeromonas hydrophila was inhibited for 6 h by 2 MIC enrofloxacin and was continuously inhibited in the entire experiment period of 24 h by 4,8 and 16 MIC enrofloxacin.In the in vitro model with elimination half-life of 168 h,the inhibitation effect of 2 MIC enrofloxacin on Aeromonas hydrophila lasted for 6 h and the bacteria regrew after that.4,8 and 16 MIC enrofloxacin showed continously inhabitative action on Aeromonas hydrophila.It concluded that con-tinous inhabitation of Aeromonas hydrophila by enrofloxacin could be achieved at the condition of AUC0→24/MIC75.24±13.24,Cmax/MIC4.10±0.12.