THE EFFECT OF DEXMEDETOMIDINE ON HYMODYNAMIC IN HYPERTENSIVE PATIENTS UNDERGOING THYROIDECTOMY

Objective To observe the effect of dexmedetomidine on hemodynamics in hypertensive patients undergoing surgery for thyroid glands. Methods Eighty hypertensive patients undergoing unilateral thyroid surgery were equally randomized to dexmedetomidine group(group D)and control group(group C).Patients in group D received a single dose of dexmedetomidine 1μg/kg 15 minutes before general anesthesia.Those in the control group were given equivalent normal saline.The HR and MAP of patients before medication(T0),at skin incision(T1),thyroid dissection(T2),upon completion of surgery(T3)were recorded,and recovery time,extubation time and RAMSAY score noted was well. Results HR and MAP in group D at T1,T2, and T3were lower than group C(t=7.04-20.32,P0.05),and in group D,the differences between two HR and MAP in different time points were significant(F=57.27,245.10;q=3.15-36.62;P0.05).The RAMSAY score in group D at extubation was higher than the control(t=8.902,P0.0).The differences between the two groups were not statistically significant in terms of time of coming around and extubation(P0.05). Conclusion Dexmedetomidine infusion before anesthesia is conducive to stabilizing hemodynamics in hypertensive patients undergoing unilateral surgery for thyroid gland,which reduces postoperative agitation and does not impact the time of analepsia and extubation.