Spironolactone combined with Enalapril in treatment of heart failure of dilated cardiomyopathy in elders

AIM To evaluate the efficiency and safety of Spironolactone combined with Enalapril in the treatment of heart failure of dilated cardiomyopathy(DCM) in elders.METHODS 148 elders with heart failure of DCM were randomly divided into the observation group(n=74) and control group(n=74).Patients in control group were treated with Enalapril plus digoxin and hydrochlorothiazide and patients in observation group were treated with drugs used in control group plus Spironolactone.After 6-week treatment,Holter and ultrasound cardiography were performed.RESULTS After treatment,(patients) in two groups showed increased left ventricular ejection fraction(LVEF),decreased left ventricular end-diastolic volume(LVEDV) and decreased times of ventricular arrhythmia in 24 h.Compared with the control group,the changes were more significant in observation group(P0.05).No hyperopotassium and impairment of liver and kidney functuins found in either group.CONCLUSION Spironolactone combined with Enalapril plus basic drugs benefit the reconstruction of left ventricular and effectively prevent sudden death.