The study on the effects of apolipoprotein E gene polymorphism on serum lipids and it's frequency distribution in Beijing natural population

Objective:The study aims at analysis of the frequency of apoE gene polymorphism in Beijing natural population and the effect of apoE gene polymorphism on serum lipid.Method:We carried out the cross -sectional study in natural population of Beijing. The study identified apoE genotypes by the technique of PCR-RFLP.Result:1. Six genotypes are found in natural population of Beijing, e3/3 account for 65.6%.The frequency of e2,e3,e4 are 9.1%,81.2% and 9.7% respectively. There are not significant difference between men and women . 2. The effect of apoE gene polymorphism is the most pronounced on LDL-C level. e2/2 has the lowest LDL-C level, e4/4 has the highest level, e3/3 is medial.3.The lipid profile of e2/2 is characteristic: LDL-C level is significantly lower than that of e3/3 ,HDL-C and VLDL-C have the increased trend. 4. Compared with e3/3,e2/3 decreases the prevalence of hypercholesterolemia; e3/4 increases the prevalence of hypertriglyceridemia combined with hypoalphalipoproteinemia.Conclusion:The frequency distribution of apoE gene polymorphism in Beijing natural population has its own traits. ApoE gene polymorphism is closely related with serum lipid. [