Angiogenesis and Tumor Metastasis

Angiogenesis plays a crucial role in tumor growth and metastases. It is becoming clear that many malignant tumors generate both stimulators and inhibitors of neovascularization, and a net balance between these position and negative regulators decides finally tumoral angiogenesis activation. Measuring the levels of some main stimulators and/or inhibitors of angiogenesis in solid tumors or in the serum or urine may reflect the information about tumor angiogenesis activation, further provides new and sensitive markers for tumor progression, metastasis and prognosis.