Therapeutic value of loop electrosurgical excision procedure in treatment of cervix uteri HPV infection

OBJECTIVE To explore the curative effect of loop electrosurgical excision procedure(LEEP)on cervical intraepithelial neoplasia(CIN) infected with high risk human papillomavirus(HPV).METHODS A total of 125 women with high risk human papillomavirus(HPV) infection and CINⅡ/Ⅲ confirmed by histology were treated by LEEP.Six months later,HPV load was measured by Hybird Capture 2(HC_2) system again.RESULTS In 52 CINⅡ cases with LEEP treatment,8 cases were cutting edge positive cases,4 cases(50.0%)were still HC_2 positive after six months;and 44 cutting edge cases negative,2 cases were still HC_2 positive with the positive rate of 4.5%.In 73 CINⅢ cases after LEEP treatment,there were 10 cutting edge positive cases(60.0%),5 cases still HC_2 positive after six months;and 63 cutting edge cases negative,3 cases were still HC_2 positive with the positive rate of 4.7%.CONCLUSION LEEP is the effective treatment of cervical lesion and can significantly decrease the HPV infection at cervix.After LEEP therapy,HPV persistence infection is relate to LEEP cutting edge positive.