Development of cervical intraepithelial neoplasia with high risk HPV infection after LEEP treatment

Objective: To study the development of cervical intraepithelial neoplasia(CIN) with high risk human papillomavirus(HR-HPV) infection after loop electrosurgical excision procedure(LEEP).Methods:A total of 109 women with high risk HPV infection and CINⅠ/Ⅱ/Ⅲ confirmed by histology were treated by LEEP.Six months later high risk HPV load was measured by HybirdcaptureⅡsystem again.The colposcopy and cervical biopsy were performed in the meantime.Results: The average high risk human papillomavirus load of CIN patients were decreased after treatment of LEEP significantly after six moths(P0.01).HPV loading turned to be negative postoperatively in 73.39%(80/109) of the women,but the negative conversion rate had no significant differences among CINⅠ/Ⅱ/Ⅲ groups(P0.05).After LEEP treatment,in the low viral loading group,7 cases turned to chronic cervictis and 1 remained CIN;in the mediumin viral loading group,7 cases turned to chronic cervictis,3 cases remained CIN;the high viral loading group,7 cases turned to chronic cervictis;4 cases remained CIN.The Positive Rate of CIN between the three groups was significant(P0.05).Conclusions: LEEP is a effective treatment of cervical lesion and can reduce the viral loading of HR-HPV at CIN significantly.The prognosis of CIN is related to high viral loading of HR-HPV after LEEP therapy.HC-II examination is useful in the prognosis of HR-HPV infection of patients with CIN.