Discussion of antimicrobial resistance of 177 isolates of Pseudomonas aeruginosacausing nosocomial infections

OBJECTIVE To investigate the specimen sources and antimicrobial resistance of Pseudomonas aeruginosa causing nosocomial infections and provide the experimental evidence for clinically reasonable use of the antibiotics.METHODS Referring to National Guide to Clinical Laboratory Procedures,the strains were cultured and identified;the drug susceptibility testing was performed by K-B methods.RESULTS The isolation rate of P.aeruginosa from respiratory tract(55.4%) was the highest,followed by the pus specimens(13.0%) and the urine specimens(12.4%);the resistance rates of P.aeruginosa to imipenem,meropenem,cefoperazone/sulbactum were the lowest,varying from 5.6% to 6.2%;the resistance rate to trimethoprim/sulfamethoxazole was the highest(55.4%);P.aeruginosa was resistant to the other commonly used antibiotics in varying degrees;no strains of pandrug-resistant P.aeruginosa was isolated from the clinical specimens.CONCLUSION The resistance rate of P.aeruginosa in grass-root hospital is distinctly lower than that in large scale general hospital in the city;the drug resistance of P.aeruginosa has been serious,so the management departments should adopt the effective measures to restrain rapidly increasing tendency of drug resistance of P.aeruginosa.