Changes of insulin resistance and function of islet β cell in gestational diabetes mellitus with different status of glucose metabolism

Objective To investigate the changes of insulin resistance (IR) and function of islet β cell in the process of GDM. Methods 35 subjects with NGT, 33 IGT and 38 GDM were observed. HOMA-IR was applied to assess the status of insulin resistance, and HOMA-β was used to evaluate the basic function of islet β cells respectively. Results HOMA-IR was higher in subjects with IGT (1.17±0.05) than that with NGT (0.88±0.04) (P0.05),and it was higher in subjects with GDM (1.56±0.06) than that with NGT and IGT (P0.05). At the same time,HOMA-β was lower in subjects with GDM (2.98±0.13) than that with NGT (5.12±0.04) and IGT(5.10±0.05)(all P0.05). Conclusions During the middle and advanced stage of pregnancy, the subjects with IGT show a defect of the early phase of insulin secretion,and the patients with GDM have more severe IR and defect of β cell function.With the deterioration of glucose metabolism from NGT to GDM,the function of islet β cells is progressively decreased.