Clinical significance of routine analysis on blood coagulation function and blood cells

Objective To explore the four indices of blood coagulation function and the physiological change of complete blood cells in parturient women,and to investigate their effect on coagulation disorders occurring during and after parturition.Methods 316 cases of parturient women(parturient group) and 130 cases of non-pregnant women(control group) were detected with Sysmex CA-50 automated blood coagulation analyzer for detection of four indices of blood coagulation function and Mayrui BC-3000 plus automated hematology analyzer for measurement of complete blood cells.Results The levels of two blood coagulation indices(prothrombin time(PT) and activated partial thromboplastin time(APTT)) and partial blood cell parameters(hemoglobin,red blood cell count,RBC parameters and platelet count) were significantly lower in parturient group than those in control group(P0.05 or 0.01).In contrast,the levels of fibrinogen(Fbg),white cell count(mainly neutrophils),mean platelet volume(MPV) and platelet distribution width(PDW) were markedly higher in parturient group than those in control group(P0.05 or 0.01).There wasn′t statistical difference of thrombin time(TT) between the two groups(P0.05).Conclusion As the blood of parturient women is in hypercoagulable state,the dynamic detection of blood coagulation indices and blood cell parameters contributes to the diagnosis and prevention of DIC and the abnormal bleeding during and after parturition.