2007•Journal of Chongqing College of EducationRequires access
Retarding the cellular senescence by Epithalon and changes of telomere length and telomerase activity in the retarding process
Tong Shi-liang
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Abstract
Objective: Observe changes of telomere length and telomerase activity during the process of retarding the cellular senescence by Epithalon polypeptide(Ala-Gly-Asp-Glu).Method: Effects of retarding the cellular senescence by Epithalon were evaluated through cell cycle analysis,detection of telomerase activity and telomere length by the means of in vitro inducing L-02 cell senescence using tert-butyl hydroperoxide(t-BHP).Results: The aging model by t-BHP induction was established.Telomere length was shortened obviously.Epithalon significantly retarded cellular senescence,reduced telomere shortening caused by t-BHP and increased telomerase activity.Conclusion: Epithalon has some anti-aging effects,could retard the shortening of telomere and prolong cell lifespan.