Comparative effect of amlodipine and levamlodipine on nocturnal hypertension in hypertensive patients

Objects:To compare the effect of amlodipine and levamlodipine on nocturnal hypertension in hypertensive patients and their influences on the circadian rhythm of blood pressure. Methods:Amlodipine (5 mg) and Levamlodipine (2.5 mg) were given once-daily to two groups (each 30) of hypertensive patients with nocturnal hypertension for 4 weeks.ABPM was performed over a 24 hour period both at baseline and the end of 4 weeks treatment. Results:The effect of Amlodipine was similar to that of Levamlodipine in the treatment of hypertensive patients with nocturnal hypertension.No significant difference was found in the effective rate between the two groups( P 0.05).Both drugs had no influences on the circadian rhythm of blood pressure. Conclusions:Both Amlodipine and Levamlodipine can effectively and steadily control the 24 hour blood pressure in hypertensive patients with nocturnal hypertension.