Measurement and clinical significance of IL-8 、IL-13 and IL-18 in serum of patients with bronchial asthma

Objective To investigate the change and significance of IL-8,IL-13 and IL-18 level in serum of patients with bronchial asthma.Methods 45 patients with acute exacerbation of bronchial asthma were selected (acute group),and remission group 45 patients and 30 healthy persons (control group) were selected.The serum IL-8,IL-13 and IL-18 levels were measured respectively by ELISA.Results The serum IL-8,IL-13 and IL-18 levels in acute group were significantly higher than that in control group and remission group ( t =5.21,5.13,4.99,5.32,5.48,5.59,P ＜ 0.05 ) ; The serum IL-8,IL-13 and IL-18 levels in remission group were significantly higher than that in control group(t =4.18,4.71,4.89,P ＜0.05).Conclusion The levels of serum IL-8,IL-13 and IL-18 may be related to the severity of asthma attack.IL-8,IL-13 and IL-18 played important role in both pathogenesis and determination of asthma. Key words: Asthma;  Interleukin-8 ;  Interleukin-13 ;  Interleukin-18