Diagnostic value of combining dynamic contrast enhanced MRI and diffusion weighted imaging in the diagnosis of breast tumorZ

Objective:To evaluate the sensitivity,specificity and accuracy of dynamic contrast enhanced imaging,diffusion weighted imaging and combination of the two methods in the charaterization of breast lesion.Methods:47 lesions of 42 patients were acquired with histopathological demonstration,of which 23 were malignant and 24 were benign.All lesions were examined with dynamic contrast enhanced MRI and DWI(b=1000s/mm2).Using integral method and statistics the sensitivity,specificity and accuracy of the dynamic enhancement curve,DWI and combination of the two methods in the diagnosis of breast lesions were comparted.Results:The threshold between benign and malignant lesions was 1.195×10-3mm2 /s by ROC curve.The sensitivity of dynamic enhancement curves,DWI and combination of both for diagnosis of breast lesions was 100%,91.3% and 95.6% respectively,specificity was 66.7%,75%,87.5% respectively and accuracy was 83%,83%,91.5% respectively.Conclusion:The specificity and accuracy of combination of dynamic contrast-enhanced MRI and DWI was higher in the diagnosis of breast lesions than either exam method,that is very helpful for characterization of breast lesions.