Role of Blood Plasma Brain Natriuretic Peptide in Diagnosis and Prognosis of Patients with Heart Failure

Objective To investigate the role of blood plasma brain natriuretic peptide(BNP) in diagnosis and prognosis of patients with heart failure(HF).Methods The level of blood plasma BNP in 93 patients with dyspnea were detected by using the fluorescence immunoassay method.LVEF were determined by heart color Doppler test.61 cases met the Framingham criteria for congestive heart failure.The functional classes were assessed by New York Heart Association(NYHA).The patients with HF were divides into group A(BNP400 pg/ml) and group B(BNP≥400 pg/ml) according to their blood plasma BNP levels.The rate of rehospitalization in 4 weeks was compared between the two groups.Results The blood plasma BNP levels of patients with HF was(583±189)pg/ml,and obviously higher than that[(49±8)pg/ml] of patients without HF,and it increased with the severity.In HF patients,the blood plasma BNP had an inverse correlation with LVEF(r=-0.67,P0.01).There was no statistical significance in the difference of blood plasma BNP levels among the patients with different primary diseases(P0.05).The rehospitalization rate of group B was higher than that of group A four weeks after the discharge(P0.05).Conclusion The blood plasma BNP levels can be referenced in the diagnosis and prognosis judgment of patients with HF.