Effects of blood glucose fluctuation on SOD,MDA,NO level of diabetic rats and protective effect of Danzhi Jiangtang Capsules

AIM To investigate the intervention of Danzhi Jiangtang Capsules( Pseudostellariae Radix,Rehmanniae Radix,Cuscutae Semen,Moutan Cortex,Hirudo Alismatis Rhizoma,etc.) in blood glucose fluctuation state of diabetic rats. METHODS The models of blood glucose fluctuation of diabetic rats were established by intraperitoneal injection of streptozotocin( STZ) combined with either subcutaneous injection with insulin or gavaging of glucose. The activity of superoxide dismutase( SOD),fasting serum insulin( FINS),and pancreatic tissue pathology were observed. RESULTS After six weeks,symptoms of polyphagia,polyuria and polydipsia of rats in Danzhi Jiangtang Capsules group were markedly improved compared with model of diabetes and blood glucose fluctuation group. Compared with the blood glucose fluctuation group,Danzhi Jiangtang Capsules increased the activity of SOD( P 0. 01) and the level of FINS( P 0. 05). The pancreatic islets in Danzhi Jiangtang Capsules group became significantly larger and increased in numbers compared with two model groups. CONCLUSION Danzhi Jiangtang Capsules can improve the ability of antioxidation and FINS in blood glucose fluctuation state,thereby reducing the symptoms.