The mRNA Expression of HE4 and Clinical Significance in Ovarian Cancer

Objective To investigate the relationship between the mRNA expression of HE4 and clincopathological features in ovarian cancer and it's clinical Significance.Methods We examined the mRNA expression of HE4 and serum levels of CA125 in control group(n=21),ovarian borderline tumor(n=21) and epithelial ovarian cancer(n=51) by RT-PCR and electrochemiluminescence method.Results The mRNA expression of HE4 and Serum levels of CA125 were significantly higher in ovarian borderline tumor and ovarian cancer than that in control group(P0.01,P0.05).The specificity and sensitivity of the mRNA expression of HE4 in ovarian borderline tumor and the sensitivity in earlier ovarian cancer and the specificity in ovarian cancer were significantly higher than serum level of CA125 respectively(P0.05).Conclusion Increased mRNA expression of HE4 were closely associated with tumorigenesis and pathobiological behaviors of ovarian cancer,therefore may be used as specific tumor markers for the detection of the benign and borderline tumor and l ovarian cancer.