Observation of curative effect of artificial liver support system in patients with drug-induced liver disease

Objective To explore the clinical efficacy and safety of artificial liver support system in the treatment of drug-induced liver disease.Methods Eighty-eight cases of drug-induced liver disease were randomly divided into 2 groups,44 cases in each group.2 groups of patients were received comprehensive treatment in the department of internal medicine;the patients in observation group were treated with artificial liver support system.Compared the changes of serum biochemical indexes including aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBil),total bile acid(TBA).prothrombin activity(PTA) in the 2 groups of patients before and after treatment,and also observed the clinical efficacy.Results After treatment,AST,ALT,TBil,TBA were significantly decreased in both of the 2 groups,PTA increased significantly,and the change degree in observation group was significantly higher than that of control group(t= 2.383,2.281,2.419,2.421,P 0.05).The observation group' s cure rate was 38.6%,the survival rate was 45.5%,death patients' mean survival time was(28.9 ±7.5) d,the control group were 15.9%,27.3%and(15.6 ±4.2) d,the effect of obsen'ation group was significantly higher than that of control group(x~2=2.365,2.281,2.263,P 0.05).During the treatment,the observation group has 72 cases that were occurred with mild complications.Conclusion Artificial liver support therapy for patients with drug induced liver disease can significantly improve the cure rate and survival rate with high safety,can be applied in clinic.