Analysis of the HBV infection status in HBsAg positive pregnant women prior to their delivery

Objective To explore the distribution of HBV infection biomarkers in HBsAg positive pregnant women,and analyze the causes of this distribution.Methods From Aug.2009 to Nov.2010,a structured questionnaire on demographic data was administered to eight hundred and ninety five HBsAg positive pregnant women,from whom blood samples were then collected to test for HBsAg,HBeAg,Anti-HBe and HBV DNA.The collected data were analyzed by SPSS software.Results Of the 895 subjects,33.4% were HBeAg-positive,and 25.2% had HBV DNA levels of ≥107 IU/mL.Among HBeAg-positive pregnant women,HBsAg titers were positively correlated with HBV DNA level(r=0.53,P0.01).There was a trend of decreased risk of mother-to-infant transmission with the increasing age.Conclusion In Chinese HBsAg-positive pregnant women,risk of HBV mother-to-infant transmission is relatively high,and delaying the age of pregnancy may lower the risk of HBV mother-to-infant transmission.