Prevalent Strains of Pathogens and Drug Resistance Analysis in ICU

OBJECTIVE To understand the characteristics of the prevalent strains of pathogens and their drug resistance in intensive care unit(ICU) and provide proofs for the rational use of antimicrobial drugs to prevent and control infections.METHODS During Jan 2008 to May 2010,various samples of bacteria from ICU were underwent a process of germ culture,identification and drug-sensitivity test,the isolated pathogens and their drug resistance were analyzed.RESULTS From the submission of various types of specimens isolated from 349 non-duplicate pathogens,the G-bacteria,accounted for 77.9%,followed by G+ cocci(12.9%) and fungi(9.2%).The major pathogens were Acinetobacter baumannii,Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli,Staphylococcus aureus,and Stenotrophomonas maltophilia,respectively,22.1%,15.2%,11.2%,6.9%,6.9% and 6.3%,mainly distributed in the lower respiratory tract,accounting for 69.3%.The rate of A.baumannii and P.aeruginosa pan-resistant strains were 7.8% and 13.2%;The detection rates of K.pneumonial and ESBLs-producing E.coli strains were 46.2% and 50.0%;the 50.0% MRSA were detected.Major pathogens to commonly used antibiotics were multi-drug resistant and pan-resistant,G+ cocci were sensitive to vancomycin and teicoplanin.CONCLUSION The pathogens prevalent strains in ICU are Gram-negative bacilli,mainly in the lower respiratory tract,the main pathogens show serious drug resistance to antimicrobial agents.Dynamic monitoring to the prevalence and drug resistance of the pathogens in ICU should be performed to standardize the rational use of antibiotics,to prevent and to reduce the drug resistant strains.