Comparison of CLIA and ELISA detection of serum anti-tuberculosis antibody

Objective To compare the value of chemiluminescence immunoassay(CLIA) TB antibody detection kit and enzyme-linked immunosorbent assay(ELISA) TB antibody detection kit on the auxiliary diagnosis of tuberculosis.Methods The level of anti-TB antibody in 360 serum were detected by the CLIA and ELISA kits,and the results were analyzed by statistical software.Results The detection rate of CLIA and ELISA kits was 71.2%(185/260) and 58.5%(152/260) in active TB group respectively,which had significant difference(P 0.05).Among 100 healthy controls,89 and 93 cases were negative detected by the two kits,the specificities was 89.0% and 93.0% respectively,which had no significant difference(P 0.05).Conclusion The CLIA kit and ELISA kit have the same specificities in the detection of anti-tuberculosis antibody,but the sensitivities of CLIA kit is significantly higher than the ELISA kit.