Expression of CC family chemokines in the tissue of chronic rhinosinusitis in Northern China

Objective To evaluate the expression and roles of chemokines in chronic rhinosinusitis without nasal polyps( CRSsNP)and with nasal polyps( CRSwNP) in Northern China. Methods Ninety-four cases of NP tissue,33 cases of sinus mucosa of CRSsNP and24 cases of control were enrolled in the present study. ELISA was used to measure CCL2( MCP-1),CCL3( MIP-1a),CCL4( MIP-1b),CCL5( RANTES) and Eotaxin in homogenization of nasal mucosa and polyp tissue. Results CCL2( MCP-1),CCL3( MIP-1a),CCL4( MIP-1b) and Eotaxin in NP tissue were significantly higher than those in CRSsNP and control tissue. CCL4( MIP-1b) and Eotaxin in eosinophilic NP tissue was significantly higher than those in neutrophilic NP. No significant difference of CCL5( RANTES) was found among the above groups. Conclusion Chemokine CCL2( MCP-1),CCL3( MIP-1a),CCL4( MIP-1b) and Eotaxin may play important roles in the pathogenesis of nasal polyps.