Clinical Observation on Shugan Jianpi Recipe plus Lamivudine for the Liver Stagnation and Spleen Deficiency Syndrome in Chronic Hepatitis B Patients:A Report of 62 Cases

Objective To observe the therapeutic effect of Shugan Jianpi Recipe (Recipe to soothe the liver and strengthen the spleen) plus Lamivudine on the liver stagnation and spleen deficiency syndrome of chronic hepatitis B.Methods Of the 180 patients with chronic hepatits B, 62 patients in the treatment group were prescribed Shugan Jianpi Recipe plus Lamivudine, 58 patients in the control group I were administered Lamivudine only, and 60 patients in the control group II were given Shugan Jianpi Recipe only. All the three groups were treated for 12 months and followed for 6 months. The changes in the liver functions, HBV DNA quantity, HBeAg, the incidence of YMDD, clinical symptoms, and the total effective rate were observed.Results After treatment for 12 months, in the treatment group, the improvement in ALT was more significant than that in the control group I (P0.05); the HBeAg negative rate in the sixth-month follow-up was significantly higher than that of the two control groups (P0.05); the HBV DNA negative rate in the sixth and twelfth-month treatment and the sixth-month follow-up was significantly higher than that of the two control groups (P0.05). When the follow-up finished, YMDD positive rate in the HBV DNA positive patients was lower than that of the control group I (P0.05). The total effective rate of the treatment group, the control group I and II was 85.5%, 65.5%, and 70.0% respectively, the difference was significant (P0.05).Conclusion Shugan Jianpi Recipe plus Lamivudine is effective for the liver stagnation and spleen deficiency syndrome of chronic hepatitis B in restoring the liver functions, improving the clinical symptoms, enhancing the anti-virus effect, and reducing the incidence of Lamivudine resistance.