Value of dynamic detection of serum C-reactive protein and D-dimer in patients with progressive cerebral infarction

Objective To explore the value of dynamic detection of serum C-reactive protein and D-dimer in patients with progressive cerebral infarction.Methods 60 cases of progressive cerebral infarction patients in Shuangshan Hos pital of Anshan City from February 2012 to January 2013 were selected as observation group and 60 cases of patients with non-progressive cerebral infarction were selected as control group.Blood C-reactive protein,D-dimer levels in the two groups were measured at next day(day 1),day 3,day 7 and day 14.Results ①Carotid stenosis rate in observation group was 43.3%(26/60) in day 1,carotid stenosis rate in control group was 30.0%(18/60),the difference was statistically significant(P 0.01);TC,TG,LDL-C in observation group in day 1 were higher than those in control group,the differences were statistically significant(P 0.01);the differences of HDL-C,blood glucose level in the two groups in day 1 were not statistically significant(P 0.05).The differences of CRP and DD level in the two groups in day 1 were not statistically significant(P 0.05).②CRP in control group in day 3,7,14 were lower than those in day 1,the differences were statistically significant(P 0.05);CRP in observation group in day 3,7 were higher than those in day 1,the differences were statistically significant(P 0.05);the difference of CRP in observation group in day 1 and day 14 was not statistically significant(P 0.05);DD levels in observation group in day 3,7,14 were higher than those in day 1,DD levels in observation group were higher than those in control group in the same term,the differ ences were statistically significant(P 0.05).Conclusion The dynamic observation of the changes of CRP and DD may contribute to early identification and timely treatment of progressing ischemic stroke.