2016•Zhongguo jiceng yiyaoRequires access
Clinical effect of urinary kallikrein in the treatment of progressive cerebral infarction and its influence on hs-CRP
Zheng Qiu, Lin Li
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Abstract
Objective
To discuss the clinical effect of urinary kallikrein in the treatment of progressive cerebral infarction and its influence on hs-CRP.
Methods
92 patients with progressive cerebral infarction were randomly divided into the observation group(n=46) and the control group(n=46) according to the digital table.The control group was treated with conventional therapy, the observation group was treated with urinary kallikrein based on the control group.The clinical effects and the influence on hs-CRP were compared between the two groups.
Results
The explicit efficiency and the effective rate of the observation group were 71.7% and 89.1%, which were significantly higher than 43.5% and 69.6% in the control group(χ2=7.522 0, 5.372 7, P<0.05 or P<0.01). After treatment, the hs-CRP levels in the two groups were (11.79±3.92)mmol/L and (10.04±3.90)mmol/L, which were significantly lower than (13.48±3.89)mmol/L and (13.54±3.93)mmol/L before the treatment(t=4.287 4, 2.075 5, P<0.05 or P<0.01), and hs-CRP of the observation group was significantly lower than the control group(t=2.146 5, P<0.05). After treatment, NIHSS scores in the two groups were (9.91±4.35)points and (6.82±4.32)points, which were significantly lower than (15.39±4.34)points and (15.43±4.37)points before treatment(t=6.048 6, 9.503 2, all P<0.01), and NIHSS score of the observation group was significantly better than the control group(t=3.418 5, P<0.01). After treatment, the Barthel in the two groups were (53.87±18.12) and (68.21±18.14), which were significantly higher than (34.35±18.08) and (34.42±18.11) before treatment (t=5.172 1, 8.943 4, all P<0.01), and Barthel of the observation group was significantly better than the control group(t=3.793 3, P<0.01). There was no obvious adverse reactions and side effects in the treatment.
Conclusion
Urinary kallikrein can effectively improve the local blood flow perfusion, restore nerve function damage and improve the living ability of the patients in the treatment of progressive cerebral infarction, it has curative effect, and it's safe and reliable, which is worthy of promotion.
Key words:
Urinary kallikrein; Cerebral infarction; CRP; Treatment outcome