Early diagnostic value of NGAL and KIM-1 in ICU patients with acute kidney injury

Objective To explore the early diagnostic significance of serum and urine neutrophil gelatinase associated lipocalin(NGAL)and urine kidney injury molecule-1(KIM-1)in ICU patients with acute kidney injury(AKI).Methods A total of 23AKI patients and 24non-AKI patients,hospitalized in ICU of this hospital from Jun.2010to May.2011,and 21healthy subjects were enrolled and detected for serum and urine NGAL and KIM-1,and serum urea nitrogen(BUN),creatinine(Cr)and cystatin C(Cys C).All data were statistically analyzed.Results Serum levels of NGAL,BUN,Cr and Cys C,and urinary levels of NAGL and KIM in AKI group were higher than healthy group(P0.01).The differences of serum levels of NGAL,BUN and Cr,and urinary levels of NGAL and KIM-1between detection before and after therapy were significant(P0.01).The differences of serum levels of NGAL and Cr,and urinary levels of NGAL and KIM-1between AKI group and non-AKI group were significant(P 0.01).Area under receiver operating characteristic curve of serum NGAL,urinary NGAL,urinary KIM-1,serum Cr,Cys C and BUN was 1.00,0.97,1.00,0.98,0.98and 0.99respectively.Conclusion The level of serum NGAL,urine NGAL and KIM-1could be increased significantly in AKI patients,which might be with early diagnostic value in AKI.