Expression and significance of serum NGAL and urine NGAL in kidney diseases

Objective To investigate the clinical change and significance of neutrophil gelatinase-associated lipocalin(NGAL) in patients with acute and chronic renal damage and the comparison with serum creatinine(Scr) and glomerular filtration rate(GRF).Methods the NGAL concentration in serum and urine were detected by ELISA in 95 Acute kidney injury(AKI) patients and 40 primary chronic kidney disease(CKD) patients,50 healthy subjects as control group.The changes of NGAL in serum and urine and relationship to glomerular filtration rate(GFR) were analyzed.The serum and urine NGAL AKI in each group divided by clinical staging criteria were also observed.Results NGAL level in the serum of the AKI group,CKD group and healthy control group were:678.6±45.3 μg/L,374.5±63.1 μg/L,49.6±8.3 μg/L;75.5±10.2 μg/L,44.3±9.8 μg/L,7.45±0.66 μg/L in urine.The NGAL in serum and urine in AKI and CKD group serum were higher than in control,the differences were statistically significant(P0.05);NGAL levels in serum and urine increased accompany with AKI phase,and NGAL levels were negatively correlated with GFR(in serum:r=-0 867,P0.05;in urine:r=-0.756,P0.05).Conclusion NGAL can be used as indicators of acute kidney injury,and the early and continuous detection of serum or urine NGAL level in critically ill patients and chronic kidney disease complicated with AKI,have great significance in the understanding of the progress of renal damage and the early development of appropriate intervention measures.