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2009•Journal of psychiatryRequires access

A comparative study of olanzapine and risperidone in the treatment of schizophrenia

Xuegang Wang

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Abstract

Objective To compare the clinical efficacy and safety between olanzapine and risperidone in the treatment of patients with schizophrenia. Methods A total of 120 patients with schizophrenia were randomly assigned into olanzapine group and risperidone group for the treatment of 6 weeks. The Positive and Negative Symptoms Scale (PANSS) was used to evaluated the efficacy, and the Treatment Emergent Symptoms Scale (TESS) was used to assess the side effects.Results The response rates were 95% for olanzapine group and 93% for risperidone group. The main side effects of olanzapine was somnolence, and those of risperidone was EPS. Conclusion Both olanzapine and risperidone are effective and safe in the treatment of schizophrenia.

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What this paper is about

Objective To compare the clinical efficacy and safety between olanzapine and risperidone in the treatment of patients with schizophrenia. Methods A total of 120 patients with schizophrenia were randomly assigned into olanzapine group and risperidone group for the treatment of 6 weeks. The Positive and Negative Symptoms Scale (PANSS) was used to evaluated the efficacy, and the Treatment Emergent Symptoms Scale (TESS) was used to assess the side effects.Results The response rates were 95% for olanzapine group and 93% for risperidone group. The main side effects of olanzapine was somnolence, and those of risperidone was EPS. Conclusion Both olanzapine and risperidone are effective and safe in the treatment of schizophrenia.

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Available abstract

Objective To compare the clinical efficacy and safety between olanzapine and risperidone in the treatment of patients with schizophrenia. Methods A total of 120 patients with schizophrenia were randomly assigned into olanzapine group and risperidone group for the treatment of 6 weeks. The Positive and Negative Symptoms Scale (PANSS) was used to evaluated the efficacy, and the Treatment Emergent Symptoms Scale (TESS) was used to assess the side effects.Results The response rates were 95% for olanzapine group and 93% for risperidone group. The main side effects of olanzapine was somnolence, and those of risperidone was EPS. Conclusion Both olanzapine and risperidone are effective and safe in the treatment of schizophrenia.

Key concepts: Risperidone, Olanzapine, Schizophrenia (object-oriented programming), Psychology, Negative symptom, Somnolence, Clinical efficacy, Psychiatry

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