2004•Zhongguo tangniaobing zazhiRequires access
A study on the relation of serum fasting true insulin level and insulin resistance with serum lipids in patients with type 2 diabetes mellitus
Gan Yu
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Abstract
Objective To explore the relationship of serum fasting true insulin (TI) level and insulin resistance (IR) with lipids in patients with type 2 diabetes(T2DM) Methods The fasting TI was determined with BA ELISA method, blood lipids and blood glucose(PG) with an enzyme method in 96 subjects with NC, 132 subjects with T2DM and 148 subjects with T2DM accompanying primary hypertension(T2DM+EH), who did not undergo any antidyslipidemia treatment for a month and antihypertensive treatment for two weeks On the basis of FPG and TI, insulin secretion function (HOMA β) and IR level (HOMA IR) were calculated Results TG and HOMA IR in both T2DM and T2DM+EH groups were significantly higher than those in NC group ( P 0 01) HDL C, HOMA β in T2DM and T2DM+EH groups were significantly lower than those in NC group ( P 0 05) HOMA IR in T2DM+EH group was significantly higher than that in T2DM group HOMA β in T2DM+EH group was higher than that in T2DM group, but the difference was not significant TG had statistically significant positive correlation with TI and HOMA IR( P 0 01), HDL C had statistically negative correlation with TI and HOMA IR ( P 0 05) in both T2DM and T2DM+EH Conclusion Serum true insulin level and insulin resistance are associated with dyslipidemia in type 2 diabetes The elevated true insulin and/or serious insulin resistance will elevate TG and decrease HDL C Insulin resistance is more associated with dyslipidemia than truly hyperinsulinemia