Analysis of related factors affecting liver function for hepatocellular carcinoma after transcatheter arterial chemoembolization

Objective: To evaluate the factors influencing on liver function in the patients with hepatocellular carcinoma after transcatheter arterial chemoembolization(TACE).Methods: TACE was performed in 126 patients with hepatocellular carcinoma.A series of influencing factors on liver function after TACE were followed up,including sex,age,preoperative tumor size,the location of the tumor,the number of tumor,existence of sham shell,cirrhosis classification on CT,surgery history of hepatocellular carcinoma,the volume of lipiodol injected,super-selective supply artery embolization,postoperative Child-Pugh grade and the times of TACE.TACE was deemed to have an influence on liver function if it could not recover to preoperative level 1 month after TACE.SPSS 17.0 software package was used for univariate analysis and multivariate logistic regression analysis to determine the factors influencing on liver function after TACE.Results: the Child-Pugh classification can not resume to preoperative levels was 20.6%(26/126) 1 month after TACE.Single variant analysis showed that sham shell,super-selective supply artery embolization of tumors,the times of TACE and cirrhosis classification were related to changes of Child-Pugh grade(P0.05).Other factors weren't associated with changes of Child-Pugh grade.Multivariate logistic regression analysis showed that the times of TACE,super-selective supply artery embolization and sham shell were the important factors influencing on liver function at 1 month after TACE.Conclusion: TACE is a safe and effective treatment for hepatocellular carcinoma.Main factors influencing on liver function at 1 month after TACE were super-selective supply artery embolizationr and existence of sham shell.