Characterization and dissolution of resveratrol/hydroxypropyl-β-cyclodextrin inclusion complex

[Objective] Resveratrol hydroxypropyl-β-cyclodextrin(HP-β-CD) inclusion complex is prepared and characterized,stoichiometry of host and guest is determined and the dissolubility is also investigated.[Methods] The inclusion complex was prepared by freezedrying method,and characterized by Fourier-transform infrared spectroscopy(FT-IR),differential scanning calorimetry(DSC) and X-ray diffractometry(XRD).Drug content and release in vitro were determined by HPLC.[Results] It was defined that Resveratrol/HP-β-CD inclusion complex formed.Resveratrol/HP-β-CD was classified as AL-type with the ratio of 1:1 between host and guest,and the complexation constant was 1621M-1by the phase solubility diagram method.Compared to the drug alone,solubility and dissolving rate of inclusion complex increased.[Conclusion] The solubility,stability and dissolving rate of drug increases in inclusion complex of Resveratrol/HP-β-CD.