Expression and Clinical Significance of survivin,VEGF-C in Human Colon Cancer

Objective To investigate the relationship between the expression of survivin,VEGF-C and the clinicopathologic parameters in colon cancer.And evaluate the clinical significance.Methods 35 colon cancer tissues,15 adjacent noncancerous specimens were obtained.Survivin,VEGF-C protein expression were evaluated by immunohistochemical analysis.Results Survivin and VEGF-C were overexpressed in colon camcer tissues(60.0%,(65.7%) were significantly higher than those in noncancerous tissues(13.3%)(P0.05).Both survivin and VEGF-C expression correlated with depth of invasion,lymph node metastasis and TNM classification(P0.05 orP0.01).On the other hand,correlations were nil with regard to gender and age of the patients,histological type and distant metastasis(P0.05).There was positive correlation between the expression of survivin and VEGF-C(P0.01).Conclusion Survivin overexpression was significantly associated with elevated VEGF-C.The co-expression of survivin and VEGF-C might play an important role in lymphatic spread of colon cancer.