Serum adiponectin concentration in patients with essential hypertension

Objective To observe the levels of serum adiponectin in patients with essential hypertension(EHP),and its relationship with blood pressure(BP).Methods Fifty patients with EHP and 30 normotensive healthy subjects(NHS)were studied.Fasting plasma adiponectin was assayed by ELISA technique,and related parameters such as BP,body mass index(BMI),fasting blood glucose,lipids,and insulin were measured.According to the typical HOMA model,insulin resistance index(IRI)was calculated.Results The level of serum adiponectin was significantly lower in EHP group than that in NHS[(7.70±2.03) mg/L vs (10.83±2.58)mg/L,P 0.01].There was a significantly negative correlation between serum adiponectin level and systolic,diastolic and mean BP in EHP group.Multiple regression analysis showed that systolic and diastolic BP were independent risk factors affacting the level of serum adiponectin in patients with EHP.Conclusion The serum adiponectin is significant lower in patients with EHP and is significantly negative correlations systolic and diastolic BP.