Interaction between hepatic lipase gene promoter -514C/T polymorphism and coronary heart disease in Han nationality

Objective To explore the interaction between hepatic lipase gene promoter -514C/T polymorphism and coronary heart disease in Han nationality. Methods The genotype of the hepatic lipase gene promoter -514C/T were detected in 127 patients with coronary heart disease and 100 controls using the polymerase chain reaction-restricted fragments length polymorphism technique. The effect of the gene polymorphism on plasma lipids, lipoproteins and apoproteins was also studied. Results No significant difference was found in the frequencies of the alleles and the genotypes be-tween the coronary heart disease and the controls, which were not related with gender, family history, smoking or body mass index. Spearman's relation analysis showed that the T allele was not related with any parameters of lipids in the patients with coronary heart disease or the controls. Logistic regression showed that the T allele was not an independent risk factor for coronary heart disease. Conclusions The hepatic lipase gene promoter -514C/T polymorphism has no obvious relationship with any lipid parameters regardless of patients with coronary heart disease or controls. The T allele is not an independent risk factor for coronary heart disease.