Experimental Study on Effect of Deep-sea Fish Oil on Blood Lipid of Rat Models with Hyperlipidemia

Objective To study the effect of deep-sea fish oil on blood lipid of rat models with hyperlipidemia. Methods The rat models with hyperlipidemia were established by feeding high-fat diet.The rats of low-dose group,moderate-dose group,and high-dose group were intragastricly administrated with 0.33 g/kg,0.66 g/kg,and 2.00 g/kg deep-sea fish oil,respectively.Serum total cholesterol(TC),triglyceride(TG) and high density lipoprotein cholesterol(HDL-C) were measured at the end of tests. Results TC values of moderate-dose and high-dose groups were significantly lower than that in hyperlipidemia model group;TG values of low-dose,moderate-dose,and high-dose groups were lower than that in hyperlipidemia model group;and HDL-C was not different among hyperlipidemia model group and the three dosages groups. Conclusion Deep-sea fish oil has the function of moderating blood lipid.