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2014•Xiandai yufang yixueRequires access

Effects of taurocholate acid on serum IgG,IL-1β,IL-6 and TNF-α level of adjuvant arthritis rats

Liu Xin-yua

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Abstract

Objective To study the effect of taurocholic acid(TCA) on serum IgG,IL-1β,IL-6 and TNF-α level of adjuvant arthritis rats,as well as the mechanism of this drug. Methods Used Freund′s complete adjuvant to establish adjuvant arthritis rat model,observed TCA on swelling of rats′ paw; tested effect of drugs on rat serum IL-1β,IL-6 and TNF-α contents. Results Compared with model group,TCA promoted the edema of paw of rats with adjuvant arthritis,improved IgG,IL-1β and IL-6 content,but had no effect on TNF-α content. At the same time,it had no effect on weights of spleen and thymus. Conclusion TCA may enhance the immune function of rats with adjuvant arthritis,and regulate cytokines.

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What this paper is about

Objective To study the effect of taurocholic acid(TCA) on serum IgG,IL-1β,IL-6 and TNF-α level of adjuvant arthritis rats,as well as the mechanism of this drug. Methods Used Freund′s complete adjuvant to establish adjuvant arthritis rat model,observed TCA on swelling of rats′ paw; tested effect of drugs on rat serum IL-1β,IL-6 and TNF-α contents. Results Compared with model group,TCA promoted the edema of paw of rats with adjuvant arthritis,improved IgG,IL-1β and IL-6 content,but had no effect on TNF-α content. At the same time,it had no effect on weights of spleen and thymus. Conclusion TCA may enhance the immune function of rats with adjuvant arthritis,and regulate cytokines.

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Available abstract

Objective To study the effect of taurocholic acid(TCA) on serum IgG,IL-1β,IL-6 and TNF-α level of adjuvant arthritis rats,as well as the mechanism of this drug. Methods Used Freund′s complete adjuvant to establish adjuvant arthritis rat model,observed TCA on swelling of rats′ paw; tested effect of drugs on rat serum IL-1β,IL-6 and TNF-α contents. Results Compared with model group,TCA promoted the edema of paw of rats with adjuvant arthritis,improved IgG,IL-1β and IL-6 content,but had no effect on TNF-α content. At the same time,it had no effect on weights of spleen and thymus. Conclusion TCA may enhance the immune function of rats with adjuvant arthritis,and regulate cytokines.

Key concepts: Medicine, Adjuvant, Arthritis, Tumor necrosis factor alpha, Immune system, Spleen, Internal medicine, Immunology

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Effects of taurocholate acid on serum IgG,IL-1β,IL-6 and TNF-α level of adjuvant arthritis rats — Research Paper | ScholarLens