Effects of probucol on the endothelial function of hyperlipidemia rats

Objective To study the effects of probucol on the endothelial function of hyperlipidemia rats.Methods Fifty SD rats were randomly divided into 5 groups: the control group(group A),high fat diet group(group B),high fat diet+VitD3(ip) group(group C),high fat diet+probucol group(group D),high fat diet+VitD3(ip)+probucol group(group E).At the 16th week,the hemodynamic study was performed,then blood samples were collected for the tests of TG,TC,HDL-C,LDL-C,NO,NOS,T-AOC,MDA activity.Then arteriae aortas were collected for HE staining.Results In high fat diet groups,the plasma levels of TG,TC,LDL-C,NO,NOS elevated(P0.01);HDL-C level decreased(P0.01).In probucol intervened rats,the plasma levels of NO,NOS,T-AOC elevated(P0.05),while TC,HDL-C,LDL-C,MDA levels decreased(P0.05).At the end of study,the extent of blood pressure decreasing after infusing sodium nitroprusside was significantly higher than acetylcholine in group C(P0.05).Conclusion Probucol can improve endothelium-dependent vascular relaxation dysfunction.