Effect of benazepril combined with amlodipine or benazepril combined with hydrochlorothiazide on the ambulatory blood pressure and its smoothness index in elderly essential hypertension patients

Objective To compare the effect of benazepril combined with amlodipine or benazepril combined with hydrochlorothiazide on the ambulatory blood pressure and its smoothness index in elderly essential hypertension patients.Methods 120 elderly essential hypertension patients were randomly divided into benazepril combined with amlodipine group or benazepril combined with hydrochlorothiazide group.All patients underwent ambulatory blood pressure checks before and after taking treatment of six months.24hSBP and 24hDBP was recorded.The 24 h SISBP,SIDBPand trough peak ratio was calculated after treatment.Both groups were compared before and after treatment among the changes of ambulatory blood pressure,smoothness index and the trough peak ratio.Results Both groups got a good blood pressure control after treatmnet.After six months treatment,there were no significant differences between the two groups in the 24hSBP and 24hDBP(P0.05),and so was the trough peak ratio of systolic and diastolic blood pressure(P0.05).The 24 h SISBPand SIDBP of amlodipine group were higher than those of hydrochlorothiazide group(P0.01 or P0.05),which was statistically different.Conclusions Compared with hydrochlorothiazide,amlodipine may more steadily lower the blood pressure,and significantly increased SI.