The effccts of 17-βestradiol on capillary ultrastructure of medulla oblongata in ovariectomized rats

Objective:To study the effects of 17-β estradiol on capillary ultrastructure of medulla oblongata in ovariectomized rats. Methods: The 30 adult femal rats were randomly divided into ovariectomy group(A group), estradiol group(B group) and sham- ovariectomy group(C group).The rats of A group and B group were bilaterally ovariectomized ,Which were injected with normalsaline 0.1 ml/d), 17-β estradiol(20 μg/kg·d -1) ,The rats of D group were sham- ovariectomy ,animals were injected with normalsaline(0.1 ml/d), for 6 weeks. Results:(1)The level of serum estradiol of A group was significantly decreased compared with C group(P0.01).The level of B group was increased compared with A group(P0.01).(2)The capillary ultrastructure of medulla oblongata were abnormal in A group, endothelial cell swelled, mitochondria dilatated and ridge breaked ,basement membrane thinked significantly, however, this changes were much milder in B group. The capillary ultrastructure were normal in C group. Conclusion: The 17-β estradiol can protect capillary of medulla oblongata in ovariectomized rats.