STUDY ON THE CHANGE OF SERUM IL-2,TNF-Α,FAS,IFN-Γ AND PERIPHERAL BLOOD T-LYMPHOCYTE SUBSETS OF APLASTIC ANEMIA

[Objective]To study the change rule of serum IL-2,TNF-α,Fas,IFN-γ and peripheral blood T-lymphocyte subsets of aplastic anemia.[Methods]32 patients with aplastic anemia in our hospital from January 2008 to December 2010 were selected as research object,and they were the observation group. 32 healthy peoples at the same time were selected as control group,then the serum IL-2,TNF-a,Fas,IFN-γ and peripheral blood T-lymphocyte subsets of two groups were detected and compared.[Results]The serum IL-2,TNF-a,IFN-γ and CD8+ of observation group were all higher than those of control group. The CD3+,Fas,CD4+ and CD4+/CD8+ of observation group were all lower than those of control group,P﹤0.05 or P﹤0.01. The change of acute patients were bigger than those of chronic patients.[Conclusion]The change of serum IL-2,TNF-a,Fas,IFN-γ and peripheral blood T-lymphocyte subsets of aplastic anemia showED its rule,and there WAS correction between the severity and the levels.