Dynamic Expression of GFAP mRNA of Cerebellar Cortex after the Infarction of Middle Cerebral Artery Supply Area in Rats

The changes of glial fibrillary acid protein(GFAP) mRNA in cerebellar cortex were observed after rat middle cerebral artery occlusion.The animal model was prepared with Longa's Bolt line blocking method(MCAO) in middle cerebral artery of rats,and the expression of GFAP mRNA was examined with real-time quantilative PCR method.The results show,GFAP mRNA has dynamic expression in the cerebellar cortex after persistent middle cerebral artery occlusion,The expression in the operated group significantly increases on the 1st,3nd and 5th day,but decreases on the 7th,10th and 14th day in compcerison with that of the sham-operated group(P0.05).After rat middle cerebral artery occlusion,there are dynamic changes of GFAP in cerebellar cortex,which occurs far away from the site of infarction and secondary damage to brain tissue may be related to the neural inhibitory factor.