The effects of vitamin A and budesonide on serum cytokines IL-4,IL-10 and IFN-γ in the rat asthma model

Objectives To investigate the effects of vitamin A and budesonide on serum cytokines IL-4,IL-10 and IFN-γ in the rat asthma model and to provide the theoretic basis for vitamin A in the prevention and treatment of bronchial asthma.Methods 42 adult female SD rats were randomly divided into three groups,The rats in group A were treated with Budesonide Group B Vitamin A and group C as the controls.There were 14 rats in each group.Blood samples were obtained to determine the IL-4,IL-10 and IFN-γ levels by the ELISA method.Results After 4th week of stimulation,there was no significant difference in serum IFN-γ,IL-4 and IL-10 levels among three groups.After 5th week of stimulation,the serum IL-10 level of Vitamin A group was significantly lower than that of Asthma group,higher than Budesonide group.The serum IL-4 level of Budesonide group was significantly lower than that of Asthma group.Conclusions The inhalation of vitamin A can make asthma serum cytokines IL-4 and IL-10 lower.