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Relationship between Diabetic Nephropathy and Subclinial Inflammatory Factors

Zhang Li

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Abstract

Objective:To investigate the changes of the sensitivity reactive protein C(hsCRP),white blood cell(WBC) and fibrinogen(FIB) in patients with diabetic nephropathy(DN).Methods:The clinical documents of 506 patients with type 2 diabetes were divided into two groups based on with /without DN.The changes of the hsCRP,WBC and FIB,and the relationship between their levels and DN were analyzed in the two groups.Results:Compared to non-DN group,the levels of hsCRP,WBC and FIB were increased obviously in DN group(P 0.05).In a multiple logistic regression analysis,after adjusting the age,gender,the ascend duration of diabetes,blood pressure,lipid,glycosylated HbA1C and body mass index(BMI),the levels of WBC and hsCRP were independent risk factors of diabetic nephropathy(OR = 1.117,1.127;95% CI:1.058-1.180,1.005-1.264).Conclusion:The levels of WBC,FIB and hsCRP are closely related with DN.These subclinical inflammatory index can be used for prognosis and evaluation of DN.

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Objective:To investigate the changes of the sensitivity reactive protein C(hsCRP),white blood cell(WBC) and fibrinogen(FIB) in patients with diabetic nephropathy(DN).Methods:The clinical documents of 506 patients with type 2 diabetes were divided into two groups based on with /without DN.The changes of the hsCRP,WBC and FIB,and the relationship between their levels and DN were analyzed in the two groups.Results:Compared to non-DN group,the levels of hsCRP,WBC and FIB were increased obviously in DN group(P 0.05).In a multiple logistic regression analysis,after adjusting the age,gender,the ascend duration of diabetes,blood pressure,lipid,glycosylated HbA1C and body mass index(BMI),the levels of WBC and hsCRP were independent risk factors of diabetic nephropathy(OR = 1.117,1.127;95% CI:1.058-1.180,1.005-1.264).Conclusion:The levels of WBC,FIB and hsCRP are closely related with DN.These subclinical inflammatory index can be used for prognosis and evaluation of DN.

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Available abstract

Objective:To investigate the changes of the sensitivity reactive protein C(hsCRP),white blood cell(WBC) and fibrinogen(FIB) in patients with diabetic nephropathy(DN).Methods:The clinical documents of 506 patients with type 2 diabetes were divided into two groups based on with /without DN.The changes of the hsCRP,WBC and FIB,and the relationship between their levels and DN were analyzed in the two groups.Results:Compared to non-DN group,the levels of hsCRP,WBC and FIB were increased obviously in DN group(P 0.05).In a multiple logistic regression analysis,after adjusting the age,gender,the ascend duration of diabetes,blood pressure,lipid,glycosylated HbA1C and body mass index(BMI),the levels of WBC and hsCRP were independent risk factors of diabetic nephropathy(OR = 1.117,1.127;95% CI:1.058-1.180,1.005-1.264).Conclusion:The levels of WBC,FIB and hsCRP are closely related with DN.These subclinical inflammatory index can be used for prognosis and evaluation of DN.

Key concepts: Diabetic nephropathy, Medicine, Fibrinogen, Internal medicine, White blood cell, Body mass index, Diabetes mellitus, C-reactive protein

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